01530nas a2200181   4500000000100000008004100001653001900042653001700061653001300078653001200091653002100103100001200124245005900136856004300195300000900238490000600247520109500253       2017                            d10aUltrastructure10aSchwann cell10aM.leprae10aleprosy10aEndothelial cell1 aKumar V00aEmerging concept on peripheral nerve damage in leprosy  uhttp://www.ijrsmhs.com/pdf/v2-i7/2.pdf  a8-180 v23 a<p><em>Leprosy is a chronic disease, caused by M. leprae where involvement and damage of peripheral nerves is a typical and unique feature. The presence of M. leprae has been shown in Schwan cells (SCs) of unmyelinated nerve fibers, macrophages, and Endothelial cell (EC). The presence of M. leprae in endothelial cells suggested that SCs are not the only target cells for M. leprae infection, but the organisms are also frequently seen in the EC of the endoneurial blood vessels (EBV). In the light of increasing resistance and complication of leprosy reaction, to dapsone (DDS) and rifampicin, Clofzamin (CLF) has been included as an essential component of multidrug therapy (MDT) in standard W.H.O. regimen. Interesting observations has been recorded by various investigators in LL patients, receiving continuous MDT for several years; viable bacilli were found in peripheral nerves whereas they had disappeared from the skin. In this article, we review the different recent pathway in understanding the possible and most frequent route of entry M.leprae into the nerve.&nbsp;</em></p>