00735nas a2200109   4500000000100000008004100001100001300042700001400055245006100069520048100130022001400611       2017                            d1 aSingh AK1 aBishai WR00aPartners in Crime: Phenolic Glycolipids and Macrophages.3 a<p>Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.</p>
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