02608nas a2200265   4500000000100000008004100001100001400042700001900056700001700075700001300092700001300105700001800118700002300136700001400159700002100173700002000194700001500214700001700229700002000246700002300266700001400289245012900303520189600432022001402328       2017                            d1 aTempark T1 aSatapornpong P1 aRerknimitr P1 aNakkam N1 aSaksit N1 aWattanakrai P1 aJantararoungtong T1 aKoomdee N1 aMahakkanukrauh A1 aTassaneeyakul W1 aSuttisai S1 aPratoomwun J1 aKlaewsongkram J1 aRerkpattanapipat T1 aSukasem C00aDapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B*13: 01 allele in the Thai population.3 a<p><strong>OBJECTIVES: </strong>A previous publication in Chinese leprosy patients showed that the HLA-B*13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B*13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous adverse reactions (SCARs) in nonleprosy patients.</p>

<p><strong>PATIENTS AND METHODS: </strong>HLA-B genotypes of 15 patients with dapsone-induced SCARs (11 drug reaction with eosinophilia and systemic symptoms, four Stevens-Johnson syndrome/toxic epidermal necrolysis), 29 control patients, and 986 people from the general Thai population were determined by the reverse PCR sequence-specific oligonucleotides probe.</p>

<p><strong>RESULTS: </strong>The HLA-B*13:01 allele was significantly associated with dapsone-induced SCARs compared with dapsone-tolerant controls (odds ratio: 54.00, 95% confidence interval: 7.96-366.16, P=0.0001) and the general population (odds ratio: 26.11, 95% confidence interval: 7.27-93.75, P=0.0001). In addition, HLA-B*13:01 associated with dapsone-induced SJS-TEN (OR: 40.50, 95% confidence interval: 2.78-591.01, P=0.0070) and DRESS (OR: 60.75, 95% confidence interval: 7.44-496.18, P=0.0001).</p>

<p><strong>CONCLUSION: </strong>This study demonstrated an association between HLA-B*13:01 and dapsone-induced SCARs including Stevens-Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms in nonleprosy patients. Moreover, these results suggest that the HLA-B*13:01 allele may be a useful genetic marker for prediction of dapsone-induced SCARs in Thai and Han-Chinese populations.</p>
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