01711nas a2200205   4500000000100000008004100001653002500042653001200067653002500079100001300104700001400117700001500131700001300146700001400159245006800173856008500241300000800326490000600334520116500340       2017                            d10aMycobacterium leprae10aleprosy10aCutaneous vasculitis1 aDiallo M1 aDiack N D1 aDiatta B A1 aNdiaye A1 aDieng M T00aNecrotizing Vasculitis Due to a Severe Type II Leprosy Reaction  uhttp://ijams.kibanresearchpublications.com/index.php/IJAMS/article/download/11/9  a1-30 v23 a<p><strong>Introduction:</strong> Despite the wide spectrum of the clinical manifestations of leprosy, necrotizing cutaneous vasculitis has rarely been reported as a manifestation of this disease. We report a case of cutaneous vasculitis due to a type II leprosy reaction, secondary to lepromatous leprosy. <strong>Case report:</strong> A 38-years-old Gambian man was admitted for necrotic and infiltrated purpura of acral distribution (limbs, ears and nose), which was associated with multiple subcutaneous inflammatory nodules, epistaxis, polyarthralgia, fever and a poor general health status. Mycobacterium Leprae was isolated from the nasal mucosa (bacillary index 3 +) and the biopsy of the purpuric lesions revealed a leukocytoclastic vasculitis. A multidrug therapy concurrently with oral corticosteroids was started with good clinical results after 4 weeks. <strong>Discussion:</strong> Cutaneous necrotizing vasculitis has been described as a rare manifestation of eryhtema nodosum leprosum in medical literature. We think, in endemic areas, erythema nodosum leprosum can be added to the list of the possible etiologies of cutaneous vasculitis.</p>