00821nas a2200193 4500000000100000008004100001653001600042653001600058653001800074653002500092653001200117100001400129700001300143245007600156300001200232490000700244520036200251022001400613 2017 d10aMacrophages10aNerve cells10aDemyelination10aPhenolic glycolipids10aleprosy1 aDunlap MD1 aKhader S00aDancing with the Stars: Phenolic Glycolipids Partners with Macrophages. a249-2510 v223 a

How Mycobacterium leprae infection causes demyelination to mediate leprosy pathogenesis has been a long-standing question. In a recent Cell paper, Madigan et al. (2017) use a zebrafish model of M. leprae infection to show that infected macrophages patrol axons to trigger mitochondrial damage and induce demyelination of nerve cells.

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