02822nas a2200229   4500000000100000008004100001653001200042653003200054653002200086653001700108653002300125653001400148100002200162700001600184700002000200245006900220856009000289300001400379490000600393520217900399022001402578       2017                            d10aleprosy10aHistopathological diagnosis10aFite Faraco stain10adisagreement10aClinical diagnosis10aagreement1 aArunagirinathan M1 aMuniswamy V1 aJeevirathinam S00aClinical and Histopathological Correlation in Hansen’s Disease  uhttp://www.pacificejournals.com/journal/index.php/apalm/article/download/1462/pdf_407  aA454-A4590 v43 a<p><strong>BACKGROUND:&nbsp;</strong>The&nbsp; present&nbsp; study&nbsp; was&nbsp; carried out&nbsp; to&nbsp; correlate&nbsp; clinical&nbsp; diagnosis&nbsp; of&nbsp; new&nbsp; leprosy&nbsp; cases&nbsp; with&nbsp; that&nbsp; of&nbsp; histopathological&nbsp; diagnosis&nbsp; of&nbsp; skin&nbsp; biopsies&nbsp; stained&nbsp; with&nbsp; Haematoxylin&nbsp; and&nbsp; Eosin&nbsp; followed&nbsp; by&nbsp; Fite&nbsp; Faraco&nbsp; stain.</p>

<p><strong>METHOD:&nbsp;</strong>Skin&nbsp; biopsies of&nbsp; 70 newly&nbsp; diagnosed&nbsp; leprosy&nbsp; patients&nbsp; were&nbsp; fixed&nbsp; in&nbsp; 10% formalin&nbsp; and&nbsp; routine&nbsp; histopathological&nbsp; examination done&nbsp; followed&nbsp; by&nbsp; special&nbsp; stain ( Fite&nbsp; Faraco )&nbsp; to&nbsp; evaluate&nbsp; the&nbsp; bacterial&nbsp; index.&nbsp;</p>

<p><strong>RESULTS:&nbsp;</strong>From&nbsp; this&nbsp; study&nbsp; it&nbsp; was &nbsp;observed&nbsp; that,&nbsp; the&nbsp; commonest&nbsp; age&nbsp; group&nbsp; affected&nbsp; by&nbsp; leprosy&nbsp; was&nbsp; 31&nbsp; to&nbsp; 50&nbsp; years,&nbsp; males&nbsp; are&nbsp; twice&nbsp; more&nbsp; commonly&nbsp; affected&nbsp; than&nbsp; females ( M:F = 1.9 : 1 )&nbsp; and&nbsp; the&nbsp; most&nbsp; commonest&nbsp; clinically&nbsp; diagnosed&nbsp; spectrum&nbsp; was&nbsp; Tuberculoid leprosy&nbsp; ( TT ).&nbsp; The&nbsp; commonest&nbsp; histopathologically&nbsp; diagnosed&nbsp; spectrum&nbsp; was&nbsp; Indeterminate&nbsp; leprosy( IL ). It &nbsp;was&nbsp; observed&nbsp; that&nbsp; there&nbsp; was&nbsp; complete&nbsp; agreement&nbsp; between&nbsp; clinical&nbsp; diagnosis&nbsp; and&nbsp; histopathological&nbsp; diagnosis&nbsp; in&nbsp; 62.85%&nbsp; cases&nbsp; and&nbsp; disagreement was&nbsp; observed&nbsp; in&nbsp; 37.15%&nbsp; cases.</p>

<p><strong>CONCLUSION:&nbsp;</strong>In&nbsp; case&nbsp; of&nbsp; confirmed&nbsp;&nbsp; discrepancy,&nbsp; the&nbsp; more&nbsp; advanced&nbsp; findings ( ie.&nbsp; towards&nbsp; the&nbsp; lepromatous&nbsp; pole )&nbsp; should&nbsp; be&nbsp; given&nbsp; greater&nbsp; weightage&nbsp; and&nbsp; the&nbsp; case&nbsp; is&nbsp; to&nbsp; be&nbsp; classified&nbsp; and&nbsp; treated&nbsp; accordingly.</p>
  a2394-6466