02277nas a2200205   4500000000100000008004100001653001900042653001900061653001900080653002700099653001200126653002200138100001200160245005900172856008300231300001000314490000700324520172600331022001402057       2016                            d10aProprioception10aPolyneuropathy10aMultibacillary10aMononeuritis multiplex10aleprosy10aElectrophysiology1 aSajid I00aLepromatous Leprosy and associated proprioceptive loss  uhttps://pdfs.semanticscholar.org/7a21/48912fca7536dc253e6cfe6380f38a1eb301.pdf  a38-410 v153 a<p><strong>Background: </strong>Leprosy presents commonly with mononeuritis multiplex, affecting mainly the exteroceptive sensations. Neuropathy with a significant afferent large fiber element is considered to be an uncommon manifestation of leprous neuropathy. Aims: To evaluate the clinical and neurophysiologic aspects of a sub set of patients with leprous neuropathy having clinical proprioceptive loss. <strong>Settings and Design:</strong> Prospective study of patients with a diagnosis of peripheral neuropathy secondary to leprosy having proprioceptive loss. <strong>Materials and Methods:</strong> Consecutive patients seen during a 2 year period (2004 and 2005) diagnosed to have leprous neuropathy with proprioceptive abnormalities on clinical examination were included. The diagnosis of leprosy was achieved by positive skin biopsy, split skin smears or nerve biopsy. Their clinical and electrophysiological characteristics were studied. Statistical methods: The results were analyzed using various tests of significance, including Pearson Chi-Square test. Values less than 0.05 were considered to be statistically significant. <strong>Results and Conclusions:</strong> We observed predominance (78.95%) of multibacillary forms of leprosy. Symmetrical neuropathies outnumbered mononeuritis multiplex (12:7). The pan sensory neuropathy had a mean duration of 24.32 months, but sometimes appeared early in the course of the disease. Areflexia and electrophysiological evidence of proximal affection was common, reflecting proximal spread of neuropathic process. Such patients have higher incidence of developing deformities and ulcerations and they represent a vulnerable sub set of patients with leprosy.</p>
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