01808nas a2200361   4500000000100000008004100001260001300042653001500055653001000070653002000080653001100100653001100111653001200122653001700134653000900151653001600160653002500176653001600201653002600217100001900243700002300262700001500285700001600300700001400316700001300330700001300343245007900356856004100435300001000476490000700486520093900493022001401432       1979                            d  c1979 Dec10aAdolescent10aAdult10aCells, Cultured10aFemale10aHumans10aleprosy10aLimulus Test10aMale10aMiddle Aged10aMycobacterium leprae10aNeutrophils10aNitroblue Tetrazolium1 aGoihman-Yahr M1 aRodríguez-Ochoa G1 aAranzazu N1 aPinardi M E1 aGomez M E1 aOcanto A1 aConvit J00aIn vitro activation of neutrophils by suspensions of Mycobacterium leprae.  uhttp://ila.ilsl.br/pdfs/v47n4a02.pdf  a570-40 v473 a<p>Activation, defined as an increase in the proportion of cells that reduce nitroblue-tetrazolium in vitro, is present in neutrophils from patients with reactional lepromatous leprosy but not in neutrophils from patients with non-reactional lepromatous leprosy. Neutrophils from patients with all forms of leprosy are equally well activated by endotoxin in vitro. We have now shown that in vitro activation induced by Mycobacterium leprae suspensions is of comparable magnitude in neutrophils from patients with all forms of leprosy (including lepromatous and reactional lepromatous leprosy). There is no intrinsic neutrophil anergy in patients with lepromatous leprosy vis-à-vis M. leprae as pertains to activation. Spontaneous activation in reactional lepromatous leprosy is likely due to an indirect mechanism, probably of immunologic nature, and not simply to the presence of circulating Mycobacterium leprae in the blood.</p>
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