01322nas a2200205   4500000000100000008004100001653001200042653002000054653001900074653002400093653001200117100001200129700001300141700001400154245007500168856007100243300001000314490000700324520078500331       2017                            d10aleprosy10aHistoid leprosy10aCryptococcosis10alepromatous leprosy10aDe-novo1 aMeena D1 aSharma S1 aChauhan P00aDe-novo Histoid Leprosy Masquerading as Cryptococcosis: A Case Report   uhttp://www.ijl.org.in/2017/7%20DK%20Meena1%20et%20al%20(45-48).pdf  a45-480 v893 a<p>Histoid leprosy is an uncommon variant of lepromatous leprosy with characteristic clinical, immunologic and bacteriologic findings. It usually manifests as relapse in lepromatous patients who are on dapsone monotherapy but uncommonly also arises <em>de-novo</em>. We report a case of de<em>-novo </em>Histoid Leprosy clinically mimicking as Cryptococcosis. Our patient mimicked cutaneous cryptococcosis because of disseminated lesions which were umblicated with central ulceration and crusting, along with firm papules. Characteristic histopathological findings, presence of mycobacteria in slit skin smears, and nerve thickening helped in arriving at diagnosis of histoid leprosy and these markers/ features should be considered for differentiating these two conditions.</p>