01037nas a2200193   4500000000100000008004100001653001300042653000900055653001200064653001500076100001400091700001200105700001400117245005100131300001000182490000700192520063100199022001300830       2017                            d10aSerpinB210aPLAU10aleprosy10aImmunology1 aPouldar D1 aTeles R1 aModlin RL00aPLAU and SerpinB2 role in apoptosis in leprosy  aAB1990 v763 a<p>Leprosy is an infectious disease, caused by <em>Mycobacterium leprae</em>, which encompasses a wide clinical spectrum based on the host immune response. At one end of the spectrum, tuberculoid leprosy (T-lep) patients manifest a strong cell-mediated immune response that restricts the growth of the pathogen, while at the other extreme, lepromatous leprosy (L-lep) patients have a weak cell-mediated immune response associated with dissemination of the infection. This spectrum also correlates with the levels of apoptosis in lesions, or evidence of programmed cell death via the activation of caspases and proteases.</p>
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