01978nas a2200241   4500000000100000008004100001653001200042653003900054653001600093653001700109100001400126700001700140700001500157700001300172700001500185700001400200700001400214245013100228300001200359490000800371520134400379022001301723       2017                            d10aleprosy10aHuman immunodeficiency virus (HIV)10aCoinfection10aInterleukins1 aPires CAA1 aQuaresma JAS1 aAarão TLS1 aSouza JR1 aMacedo GMM1 aNeto FOMJ1 aXavier MB00aExpression of interleukin-1β and interleukin-6 in leprosy reactions in patients with human immunodeficiency virus coinfection  a213-2160 v1723 a<p>Previous studies suggest that coinfection of leprosy and human immunodeficiency virus (HIV) does not decrease the frequency and intensity of leprosy reactions. However, the immunological aspects of leprosy reactions in coinfected patients remain obscure, with a limited number of studies showing contradictory results. Observational study using tissue samples collected during leprosy reactions from 15 patients coinfected with leprosy and HIV and from 15 patients with leprosy alone. Patients were part of a prior larger cohort study of leprosy patients with and without HIV coinfection. Specific antibodies were used to detect IL-1β and IL-6 expression in skin biopsy tissue cells. IL-1β and IL-6 expression was similar between leprosy patients with and without HIV coinfection (p&nbsp;&gt;&nbsp;0.05). Coinfected and non-coinfected tissues showed similar levels of IL-1β and IL-6 expression for type 1 reactions. A trend towards increased levels of IL-1β and IL-6 expression was observed in tissue from coinfected patients (p&nbsp;=&nbsp;0.0024). The expression of IL-1β and IL-6 during leprosy reactions did not differ significantly between tissues obtained from leprosy patients with and without HIV coinfection. Therefore, we conclude that HIV coinfection does not affect the immunological pattern of leprosy reactions.</p>
  a0001706X