02616nas a2200433   4500000000100000008004100001260001300042653001500055653001000070653000900080653002000089653002400109653001100133653001200144653001100156653001800167653002800185653001200213653000900225653001600234653001800250653002400268653001700292100001400309700001300323700001200336700001200348700001600360700001800376700001400394700001700408700001700425245014400442856005900586300001000645490000700655520150600662022001402168       2002                            d  c2002 Sep10aAdolescent10aAdult10aAged10aChronic Disease10aDouble-Blind Method10aFemale10aFingers10aHumans10aImmunotherapy10aLaser-Doppler Flowmetry10aleprosy10aMale10aMiddle Aged10aMycobacterium10aRegional Blood Flow10aTime Factors1 aAbbot N C1 aBeck J S1 aFeval F1 aWeiss F1 aMobayen M H1 aGhazi-Saidi K1 aDowlati Y1 aVelayati A A1 aStanford J L00aImmunotherapy with Mycobacterium vaccae and peripheral blood flow in long-treated leprosy patients, a randomised, placebo-controlled trial.  uhttp://www.ejves.com/article/S1078-5884(02)91716-8/pdf  a202-80 v243 a<p><b>OBJECTIVE: </b>to evaluate immunotherapy as a means of improving peripheral blood flow in chronic leprosy patients.</p><p><b>DESIGN: </b>this was a double-blind, randomised, placebo-controlled, clinical trial.</p><p><b>MATERIALS: </b>heat-killed Mycobacterium vaccae 1mg plus 0.02 microg Tuberculin protein per 0.1 ml dose in borate buffer, with saline as placebo. Those studied were 92 long-treated residents of a leprosy centre in Iran, 10 of their healthy children and 10 staff members. Evaluation employed the Perimed PF2, Laser-Doppler Flowmeter, a platinum skin thermistor, and a thermal sensibility tester.</p><p><b>METHODS: </b>single intradermal injections of test or placebo were given to 103 patients 18 months before the blinded evaluation. Fingerpulp blood flux was measured in controlled conditions and vasomotor reflexes and skin sensation to touch, pain and heat were evaluated in 45 and 47 patients in the placebo and M. vaccae groups, respectively, and in 20 healthy control persons.</p><p><b>RESULTS: </b>Laser-Doppler flux, skin temperature, vasomotor reflexes and sensation were impaired in leprosy patients. Immunotherapy improved (p < 0.05) Laser-Doppler flux, skin temperature and temperature sensation.</p><p><b>CONCLUSIONS: </b>immunotherapy, given 18 months earlier, significantly improved blood flow and temperature sensation, in fully-treated, chronic, leprosy patients. The same principles might be employed in other conditions of reduced peripheral blood flow.</p>  a1078-5884