01180nas a2200193   4500000000100000008004100001653001700042653002600059653002200085653002000107653001300127653001100140100001300151245003300164300001200197490000700209520075600216022001400972       2017                            d10aInflammation10aParkinson’s disease10aCrohn’s disease10aInnate immunity10aCytokine10aKinase1 aDzamko N00aLRRK2 and the Immune System.  a123-1430 v143 a<p>Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been biochemically linked to the intertwined pathways regulating inflammation, mitochondrial function, and autophagy/lysosomal function. This review outlines what is currently understood about LRRK2 function in the immune system and the potential implications of LRRK2 dysfunction for diseases genetically linked to this enigmatic enzyme.</p>
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