01117nas a2200133   4500000000100000008004100001100001100042700001100053245005700064300001200121490000700133520082900140022001400969       2017                            d1 aKaur G1 aKaur J00aMultifaceted role of lipids in Mycobacterium leprae.  a315-3350 v123 a<p>Mycobacterium leprae must adopt a metabolic strategy and undergo various metabolic alterations upon infection to survive inside the human body for years in a dormant state. A change in lipid homeostasis upon infection is highly pronounced in Mycobacterium leprae. Lipids play an essential role in the survival and pathogenesis of mycobacteria. Lipids are present in several forms and serve multiple roles from being a source of nutrition, providing rigidity, evading the host immune response to serving as virulence factors, etc. The synthesis and degradation of lipids is a highly regulated process and is the key to future drug designing and diagnosis for mycobacteria. In the current review, an account of the distinct roles served by lipids, the mechanism of their synthesis and degradation has been elucidated.</p>
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