01586nas a2200349   4500000000100000008004100001260001300042653001000055653001000065653001800075653003100093653001100124653001100135653002100146653002100167653002100188653002000209653001200229653000900241653001300250653001400263653002600277100001900303700001600322700001700338700001500355245018000370300001100550490000700561520065400568022001401222       1975                            d  c1975 Dec10aAdult10aChild10aComplement C310aComplement System Proteins10aFemale10aHumans10aImmunoglobulin A10aImmunoglobulin G10aImmunoglobulin M10aImmunoglobulins10aleprosy10aMale10aPedigree10aPhenotype10aPolymorphism, Genetic1 aSrivastava L M1 aAgarwal D P1 aBenkmann H G1 aGoedde H W00aBiochemical, immunological and genetic studies in leprosy. III. Genetic polymorphism of C3 and immunoglobulin profile in leprosy patients, healthy family members and controls.  a426-300 v263 a<p>148 members from 30 families (64 children) from Ethiopia, where one of more persons were affected with leprosy, were investigated for genetic polymorphism of C3, serum concentration of ss1C/ss1A-globulin and immunoglobulins A, G and M using high voltage agarose electrophoresis, immunoelectroassay and single radial immunodiffusion techniques respectively. The results are compared with related healthy controls. No association between C3 phenotypes and leprosy could be established through family studies. C3 concentration was, however, lower in leprosy patients. Difficulties and drawbacks of such studies with small families are discussed.</p>  a0303-4208