00996nas a2200157   4500000000100000008004100001260003900042653004000081653001200121100001700133245009100150856007100241300001100312050002300323520049200346       2017                            d  bUniversity of AmsterdamaAmsterdam10aAmyotrophic Lateral Sclerosis (ALS)10aleprosy1 aEl Idrissi B00aComplement in neuroinflammation : Studies in leprosy and Amyotrophic Lateral Sclerosis  uhttp://hdl.handle.net/11245.1/6455df2c-f9a6-403a-8061-7260d7446e3b  a275 p.  aBAHIAELIDRISSI20173 a<p>The complement system is a part of the innate immunity, and plays an important role in host immunity and inflammation. We previously identified the terminal membrane attack complex (MAC) of the complement system as a key determinant of neurodegeneration and demonstrated that its inhibition is neuroprotective. Besides being part of a mechanism of defence to invading pathogens, MAC has the capacity to cause damage to self-cells and is consequently implicated in many diseases.</p>