01665nas a2200205   4500000000100000008004100001653003900042653002000081653001500101653002200116100001200138700001000150700001100160700001200171700001100183245006600194856010300260490000700363520108900370       2016                            d10aNeglected tropical diseases (NTDs)10aschistosomiasis10aSalmonella10aSub-Sahara Africa1 aHsiao A1 aToy T1 aSeo HJ1 aMarks F1 aLok JB00aInteraction between salmonella and schistosomiasis: A review.  uhttp://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005928&type=printable0 v123 a<p>The interaction between schistosomiasis and Salmonella is a particularly important issue in Africa, where dual infection by the parasite and the bacterium are likely common. In this review, the ways in which schistosomiasis affects human biology as it relates to Salmonella are described. Those who are infected by both organisms experience reduced immunological functioning, exhibit irreversible organ damage due to prolonged schistosomiasis infection, and become latent carriers of Salmonella enterica serotypes Typhi and Paratyphi and S. Typhimurium. The sequestration of the bacteria in the parasite leads to ineffective antibiotic treatment because the bacteria cannot be completely killed, and lingering infection may then lead to antimicrobial resistance. These manifestations are likely not just for those dually infected but also for those first infected with schistosomes and, later, Salmonella. More data are needed to better understand dual infection, particularly as it may impact treatment and prevention of schistosomiasis and Salmonella in sub-Saharan Africa.</p>