01404nas a2200217   4500000000100000008004100001653003300042653001700075653001500092653001200107653001800119653002900137100001400166700001300180700001400193700001200207245011000219050001600329520082700345022001401172       2016                            d10aMycobacterium indicus pranii10aMycobacteria10aMw vaccine10aleprosy10aImmunotherapy10aGranulomatous dermatitis1 aKhullar G1 aNarang T1 aSaikia UN1 aDogra S00aGeneralized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy.  aKULLAR 20163 a<p>Mycobacterium w (Mw) vaccine is a heat-killed suspension derived from a nonpathogenic, cultivable, atypical mycobacterium named Mycobacterium indicus pranii. Mw immunotherapy has been reported to be efficacious as an adjunct to multidrug therapy multibacillary regimen in leprosy patients with high bacillary index. Cutaneous reactions are predominant adverse effects associated with the administration of vaccines. Cutaneous adverse effects ascribed to Mw vaccine are generally limited to the site of injection. We herein describe two cases of lepromatous leprosy who developed an unusual generalized cutaneous reaction following Mw immunotherapy. A high index of suspicion is needed to identify such manifestations in leprosy cases to avoid misdiagnosis of a relapse or a reaction and for appropriate treatment.</p>
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