01095nas a2200169   4500000000100000008004100001653002400042653002400066653003500090653003500125653003400160100001400194700001300208245003800221856006300259520060300322       2016                            d10aTuberculoid leprosy10alepromatous leprosy10aBorderline-tuberculoid leprosy10aBorderline-lepromatous leprosy10aBorderline-borderline leprosy1 aBokhary M1 aPhung TL00aMolecular Pathogenesis of Leprosy  uhttp://link.springer.com/article/10.1007/s40475-016-0094-y3 a<p>Leprosy is a chronic infectious granulomatous disease caused by the obligate intracellular bacteria <em>Mycobacterium leprae. M. leprae</em> causes symptoms in the skin, peripheral nerves, and other tissues. Type 1 (reversal reaction) and type 2 (erythema nodosum leprosum) lepra reactions are the main mechanisms of skin lesions, nerve damage, and other types of tissue damages. Susceptibility to mycobacterial infection and the clinical presentations of the disease are associated with aberrant host immune response, which forms the spectrum and pathologic manifestations of the disease.</p>