01492nas a2200253   4500000000100000008004100001260001300042653001000055653001100065653001100076653001200087653000900099653001600108653000900124100001200133700001500145700001400160245007900174856026000253300001100513490000800524520069200532022001401224       1975                            d  c1975 Dec10aAdult10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aSkin1 aRea T H1 aGottlieb B1 aLevan N E00aApparently normal skin in lepromatous leprosy: histopathological findings.  uhttps://cdn.edhub.ama-assn.org/ama/content_public/journal/derm/14050/archderm_111_12_004.pdf?Expires=1709269732&Signature=NXOzqNKu3wY7Pu7iEPBqbQIOkJwvyWMGS1hii0mVs~pOQXT4ogHoZpAHYEyHdJHigwXBV-Qs4PpzmXv074hDYcA1gGR-HekNVN1J1glKSp-VAazzwE0alrW3KAQQHm8uQdCwG  a1571-40 v1113 a<p>Biopsy specimens of apparently uninvolved skin from 34 patients with lepromatous leprosy were studied histologically. Bacilli were found in 30 of 31 specimens from clinically polar or near-polar lepromatous patients but not in the three from nonpolar patients. A predominantly perivascular distribution of infiltrate and bacilli is consistent with a hematogenous spread of infection. Subclinical, diffuse lepromatous leprosy is found in patients with nodular lesions and may precede the development of nodules. Study of apparently uninvolved skin may be helpful in classifying patients, in interpreting immunologic responses, and in elucidating the natural history of the illness.</p>  a0003-987X