01526nas a2200349   4500000000100000008004100001260001300042653001000055653001800065653001300083653001300096653002200109653002800131653001400159653002600173653002100199653001600220653002000236653001100256653001600267653001100283653001200294653000900306653000900315100001300324700001300337245008100350300001100431490000700442520071300449022001401162       1975                            d  c1975 Dec10aAdult10aBlood Vessels10aCicatrix10aCollagen10aConnective Tissue10aConnective Tissue Cells10aCytoplasm10aEndoplasmic Reticulum10aErythema Nodosum10aFibroblasts10aGolgi Apparatus10aHumans10aHypertrophy10aKeloid10aleprosy10aMale10aSkin1 aDyer R F1 aEnna C D00aUltrastructure of keloid: an unusual incident involving lepromatous leprosy.  a743-540 v143 a<p>A patient with lepromatous leprosy developed keloids on the dorsum of both arms in response to ulcerations due to acute erythema nodosum leprosum reactions. Electron microscopic examination of the keloidal dermis showed a morphology indicative of increased production of normal collagen fibrils. The greatest cellular changes from normal were in fibroblasts which were enlarged due to increased amounts of rough endoplasmic reticulum and extensive Golgi complexes. Nuclear folds were also evident in these fibroblasts. Some cells, considered to be fibroblasts, were filled with cytoplasmic filaments and contained bizarre shaped nuclei. Mast cells, blood vessels and nerve processes were also present.</p>  a0011-9059