01846nas a2200313   4500000000100000008004100001260001700042653001000059653002300069653001100092653001100103653002300114653001300137653001200150653002600162653000900188653002500197653000900222100001600231700001100247700001600258700002000274245009800294300001100392490000700403050003200410520107600442022001401518       2001                            d  c2001 Oct-Dec10aAdult10aAntibody Formation10aFemale10aHumans10aImmunity, Cellular10aLepromin10aleprosy10aLymphocyte Activation10aMale10aMycobacterium leprae10aSkin1 aNarayan N P1 aRamu G1 aDesikan K V1 aVallishayee R S00aCorrelation of clinical, histological and immunological features across the leprosy spectrum.  a329-420 v73  aInfolep Library - available3 a<p>The Ridley-Jopling system of classification of the variegated clinical pattern of leprosy is based on the specific cell-mediated immunity observed in the histopathology of skin lesions conforming to a spectrum from TT at one end to LL at the other. In this study a fairly large sample of 90 patients was classified on clinical grounds; the histopathology of the skin lesions was studied blind. There was an overall concordance of 90% between the clinical and histological classifications. In addition, the systemic cell-mediated and humoral immune responses were studied. The in vivo cell-mediated immune response, namely the Mitsuda skin response, mostly conformed to the clinical classification. While the in vitro lymphoproliferative responses to BCG and its sonicate were high, the lymphoproliferative responses to Dharmendra lepromin were surprisingly poor. Humoral responses to 35 kDA protein of M. leprae and PGL-1 were good in most LL, BL patients and tapered off towards TT. IgG antibodies to recombinant ML 65 kDa proteins denoted mycobacterial presence.</p>  a0254-9395