01777nas a2200373   4500000000100000008004100001653002900042653000900071653001300080653001400093653000800107653001200115653001000127653000800137653001100145653000900156653000900165653000800174653000900182100001700191700001700208700001300225700001200238700001100250700001400261700001900275700001300294700001500307245012100322300001000443490000700453520092900460022001401389       2016                            d10aBimolecular interactions10aCD6810aCeramide10aEpistasis10aLAM10aleprosy10aNerve10aPGL10aPlasma10aS10010aSkin10aTGF10aiNOS1 aSuneetha L M1 aMarsakatla P1 aRavi G V1 aSykam A1 aRaju R1 aReddy P P1 aHara Gopal V V1 aJadhav R1 aSuneetha S00aPhenotypic characterization of a pair of molecules in tissues confer to classical Mendelian or non Mendelian ratios.  a112-70 v943 a<p>Studies have reported a wide range of inflammatory responses in the nerve, skin and plasma of leprosy patients. The expression levels of each biomolecule was individualistic, however could be categorized as high and low based on their statistical mean level. Here we report for the first time, expression of a set of biomolecules relating with each other in a defined proportion. The hypothesis of this paper is that the segregation of high and low combinations of a set of biomolecules follows either classical Mendelian dihybrid ratio or epistatic ratios. This hypothesis was tested for 17 molecules in three tissues; nerve, skin and plasma and were confirmed to interact in 9:7, 9:3:4, 12:3:1, 13:3, 15:1 epistatic proportions. These findings suggest that there could be a significant role of networking of molecules in defined epistatic proportions and could be important in pathophysiology of peripheral nerve.</p>
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