01534nas a2200181   4500000000100000008004100001653001200042653004300054653001800097100002400115700002300139700002300162700002100185700002100206245015100227520096000378022001401338       2016                            d10aleprosy10aMacrophage Migration Inhibitory Factor10aPolymorphisms1 aMartinez-Guzman M A1 aAlvarado-Navarro A1 aPereira-Suarez A L1 aMuñoz-Valle J F1 aFafutis-Morris M00aAssociation between STR -794 CATT5-8 and SNP -173 G/C polymorphisms in the MIF gene and Lepromatous Leprosy in Mestizo patients of western Mexico.3 a<p>Lepromatous Leprosy (LL) is the most common presentation of leprosy in Mexico. LL patients are unable to activate an effective inflammatory response against Mycobacterium leprae probably due to the genetics of the host. Macrophage Migration Inhibitory Factor (MIF) is important to trigger inflammation processes. Two polymorphisms have been reported for human MIF: STR -794 CATT5-8 and SNP -173 G/C. 7-8 CATT repeats at -794 and the C allele at -173 increase the expression of MIF. We aim to determine the association between the polymorphisms in MIF gene and LL. We carried a case and controls study with 100 Mexican LL patients and 100 healthy subjects (HS). PCR was used for genotyping of STR -794 CATT5-8 polymorphism and PCR-RFLP for -173 G/C. We found that LL patients possess high -794 CATT repeats (47.1%) more often than HS (32.7%). In conclusion, a MIF polymorphism is associated with susceptibility to LL in Western Mexican population.</p>
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