01855nas a2200349   4500000000100000008004100001260001300042653001200055653001400067653002700081653001100108653001200119653002800131653000900159653002500168653000900193653002200202653002100224653001500245100001100260700001200271700001200283700001600295700001200311700001300323700001600336245016300352300001000515490000700525520095900532022001401491       2002                            d  c2002 Feb10aAnimals10aCytokines10aDisease Susceptibility10aFemale10aleprosy10aMacrophages, Peritoneal10aMale10aMycobacterium leprae10aRats10aRats, Inbred F34410aRats, Inbred SHR10aRats, Nude1 aYogi Y1 aEndoh M1 aBanba T1 aKobayashi M1 aKatoh H1 aSuzuki K1 aNomaguchi H00a[Susceptibility to Mycobacterium leprae of congenic hypertensive nude rat (SHR/NCrj-rnu) and production of cytokine from the resident peritoneal macrophages].  a39-450 v713 a<p>We have established a congenic hypertensive nude rat strain, SHR/NCrj-rnu, carrying nude (rnu) and hypertension genes which was produced using females of the SHR/NCrj rat and males of the F344/NJcl nude rat by cross-intercross system for 12 generations. We demonstrated the susceptibility to M. leprae infection of SHR/NCrj-rnu rats as compared with F344/NJcl-rnu rats. SHR/NCrj-rnu rats were highly susceptible to M. leprae, and the SHR/NCrj-rnu rats of both sexes showed massive swelling of legs due to multiplication of M. leprae. However, F344/NJcl-rnu rats of both sexes revealed very poor susceptibility to M. leprae. There was a wide difference in the susceptibility to M. leprae between the SHR/NCrj-rnu and the F344/NJcl-rnu rats. We also examined the cytokine production. The resident peritoneal macrophages of SHR/NCrj-rnu rats produced IL-1 alpha, IL-6, IL-10 and TNF alpha, whereas those of F344/NJcl-rnu rats produced only TNF alpha.</p>  a1342-3681