01699nas a2200217   4500000000100000008004100001100001300042700001200055700001600067700001700083700001600100700001700116700001600133700001700149700001500166700001500181700001400196245008900210520116800299022001401467       2016                            d1 aAssadi G1 aSaleh R1 aHadizadeh F1 aVesterlund L1 aBonfiglio F1 aHalfvarson J1 aTörkvist L1 aEriksson A S1 aHarris H E1 aSundberg E1 aD'Amato M00aLACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis.3 a<p>The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). We selected 11 LACC1 tagging SNPs, and tested their effect on disease risk in 3855 Swedish individuals from three case-control cohorts of CD, UC and JIA. We detected false discovery rate corrected significant associations with individual markers in all three cohorts, thereby expanding previous results for CD also to UC and JIA. LACC1's link to several inflammatory diseases suggests a key role in the human immune system and justifies further characterization of its function(s).Genes and Immunity advance online publication, 21 April 2016; doi:10.1038/gene.2016.17.</p>
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