02369nas a2200337   4500000000100000008004100001260001300042653001500055653001000070653002200080653001200102653001900114653001100133653001100144653003400155653001800189653001200207653001600219653000900235653001600244653002000260100001100280700001500291700001900306245013500325856007800460300001100538490000600549520146200555022001402017       1975                            d  c1975 Mar10aAdolescent10aAdult10aBlood Transfusion10aDapsone10aDrug Tolerance10aFemale10aHumans10aImmunity, Maternally-Acquired10aImmunotherapy10aleprosy10aLymphocytes10aMale10aMiddle Aged10aTransfer Factor1 aSaha K1 aMittal M M1 aMaheshwari H B00aPassive transfer of immunity into leprosy patients by transfusion of lymphocytes and by transfusion of Lawrence's transfer factor.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC275059/pdf/jcm00235-0057.pdf  a279-880 v13 a<p>About 1,200 million viable lymphocytes from normal but lepromin- and tuberculin-positive human beings were transfused in four patients of lepromatous and one of tuberculoid leprosy three times at monthly intervals. Three patients of lepromatous leprosy suffered from erythema modosum, whereas the other two developed severe reaction whenever put on the smallest dose of dapsone. In one patient of lepromatous leprosy, minimal improvement or none was observed, whereas in the remaining three cases of lepromatous and one of tuberculoid leprosy, clinical, bacteriological, as well as histological improvement occurred. Two of the five patients started to tolerate the dapsone during the period of study. The present study indicates that immunotherapy might have a definite role in the management of the disease especially in cases with erythema nodosum. Lawrence factor, prepared from leucocytes of normal donors, was transfused three times into four lepromatous leprosy patients who were intolerant to anti-leprosy drugs. The donors were healthy but were tuberculin and lepromin (Mitsuda) positive. The clinical, histological, bacteriological (morphological index), and immunological assessments of the patients were performed before and 5 months after starting the immunotherapy. In two patients conversion of Mitsuda reaction occurred, but there was no appreciable improvement in the clinical, histologic, and bacteriologic status of these patients.</p>  a0095-1137