01129nas a2200181   4500000000100000008004100001653001200042100001600054700001200070700001500082700001200097700001300109700001200122245013500134856007200269520059200341022001400933       2016                            d10aleprosy1 aCorstjens P1 aHooij A1 aKon Fat ET1 aEeden S1 aWilson L1 aGeluk A00aField-friendly test for monitoring multiple immune response markers during onset and treatment of exacerbated immunity in leprosy.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895013/pdf/zcd515.pdf3 a<p>Acute inflammatory reactions represent the major cause of irreversible neuropathy in leprosy. These tissue destructive episodes have considerable overlap with acute immunological complications (flares) in several chronic (autoimmune) diseases, which similarly warrant early detection. However, the lack of diagnostic tests impedes early diagnosis of reactions. Here, we evaluated a user-friendly, multiplex lateral flow assay for simultaneous detection of IP-10 and anti-phenolglycolipid-I antibodies for longitudinally monitoring early onset and treatment of leprosy reactions.</p>
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