02492nas a2200373   4500000000100000008004100001260001300042653003100055653000900086653002200095653001600117653001700133653002000150653001400170653001100184653001700195653001200212653000900224653001600233653001600249653001700265653002400282653001700306100001500323700001500338700001500353245008600368856005900454300001000513490000700523050003200530520154200562022001402104       2001                            d  c2001 Sep10a24,25-Dihydroxyvitamin D 310aAged10aAged, 80 and over10aAmino Acids10aBone Density10aBone Remodeling10aEstradiol10aHumans10aHypogonadism10aleprosy10aMale10aMiddle Aged10aOsteocalcin10aOsteoporosis10aParathyroid Hormone10aTestosterone1 aIshikawa A1 aIshikawa S1 aHirakawa M00aOsteoporosis, bone turnover and hypogonadism in elderly men with treated leprosy.  uhttp://leprev.ilsl.br/pdfs/2001/v72n3/pdf/v72n3a11.pdf  a322-90 v72  aInfolep Library - available3 a<p>In male hypogonadism associated with bone loss, it is important to determine whether bone loss continues with ageing and an increased risk of fracture. We studied bone metabolism in 86 male leprosy patients, who were classified according to the presence or absence of osteoporosis. Osteoporosis was present when men had lumbar compression fractures or a mean BMD-2SD that of normal Japanese men in each age decade. Four men had fractures. Serum concentrations of 1,25-dihydroxyvitamin D and high-sensitivity parathyroid hormone were almost normal in both groups, whereas free testosterone and oestradiol were significantly lower in the osteoporosis group than in the non-osteoporosis group (free testosterone: P < 0.01, oestradiol: P < 0.05). The urinary concentrations of pyridinoline and deoxypyridinoline, as a marker of bone absorption, were significantly higher in the osteoporosis group than in the non-osteoporosis group (pyridinoline: P < 0.01, deoxypyridinoline: P < 0.01). The serum concentration of osteocalcin, a marker of bone formation, was significantly higher in the osteoporosis group than in the non-osteoporosis group (P < 0.01). Elevated concentration means that bone repair is increased possibly because of compensation mechanisms for increased bone loss. In the osteoporosis group, hypogonadism occurred, and high bone turnover continued even in older men. We recommend clinical studies of treatment such as replacement therapy to prevent bone loss and increasing risk of fractures in older men with leprosy.</p>  a0305-7518