01416nas a2200337   4500000000100000008004100001260001300042653002100055653001200076653002400088653002300112653002300135653000900158653001200167653000900179653002500188653001600213653001800229653001400247100001400261700001600275700001600291700001300307700001600320245012900336856004100465300000900506490000700515520054200522022001401064       2001                            d  c2001 Jun10aAcyltransferases10aAnimals10aAntigens, Bacterial10aBacterial Proteins10aBacterial Vaccines10aFoot10aleprosy10aMice10aMycobacterium leprae10aVaccination10aVaccines, DNA10aVirulence1 aRoche P W1 aNeupane K D1 aFailbus S S1 aKamath A1 aBritton W J00aVaccination with DNA of the Mycobacterium tuberculosis 85B antigen protects mouse foot pad against infection with M. leprae.  uhttp://ila.ilsl.br/pdfs/v69n2a01.pdf  a93-80 v693 a<p>A DNA vaccine composed of the gene for the common mycobacterial secreted protein antigen 85B was demonstrated to protect the mouse foot pad against infection with Mycobacterium leprae. The protective effect was demonstrated by a 61%-88% reduction in the bacterial number, a protective effect less than that of BCG. The same DNA vaccine has been shown to protect mice against M. tuberculosis infection, and the importance of testing other candidate tuberculosis vaccines for their potential to protect against leprosy is discussed.</p>  a0148-916X