02033nas a2200445 4500000000100000008004100001260001600042653001700058653000900075653001200084653002500096653001000121653001800131653001100149653001900160653003200179653002000211653002000231653001100251653001200262653002800274653002800302653000900330653001600339100001200355700001000367700001100377700001100388700001000399700001200409700001000421700001000431700001000441700001000451245014400461300000800605490000700613520095300620022001401573 2009 d c2009 Dec 11 10 aAge of Onset 10 aAged 10 aAlleles 10 aCase-Control Studies 10 aChina 10 aEthnic Groups 10 aFemale 10 aGene Frequency 10 aGenetic Association Studies 10 aHLA-DR Antigens 10 aHLA-DRB1 Chains 10 aHumans 10 aleprosy 10 aLeprosy, Multibacillary 10 aLeprosy, Paucibacillary 10 aMale 10 aYoung Adult 1 aZhang F 1 aLiu H 1 aChen S 1 aWang C 1 aZhu C 1 aZhang L 1 aChu T 1 aLiu D 1 aYan X 1 aLiu J 00 aEvidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population. a133 0 v10 3 aBACKGROUND: Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to Mycobacterium leprae. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.
METHODS: The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.
RESULTS: The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.
CONCLUSION: HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.
a1471-2350