01707nas a2200433   4500000000100000008004100001260001300042653002400055653001200079653002500091653002400116653002300140653002300163653002700186653002700213653001200240653000900252653002400261653002800285653002500313653003100338653003200369653003100401653003400432653002600466100001500492700001500507700001600522700002400538700001400562700001400576700001500590245007500605856006900680300001100749490000700760520049200767022001401259       2002                            d  c2002 Feb10aAmino Acid Sequence10aAnimals10aAntibody Specificity10aAntigens, Bacterial10aBacterial Proteins10aCloning, Molecular10aEpitopes, B-Lymphocyte10aEpitopes, T-Lymphocyte10aleprosy10aMice10aMice, Inbred BALB C10aMolecular Sequence Data10aMycobacterium leprae10aMycobacterium tuberculosis10aRecombinant Fusion Proteins10aSequence Analysis, Protein10aSequence Homology, Amino Acid10aSubcellular Fractions1 aSpencer JS1 aMarques MA1 aLima MC B S1 aJunqueira-Kipnis AP1 aGregory B1 aTruman RW1 aBrennan PJ00aAntigenic specificity of the Mycobacterium leprae homologue of ESAT-6.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC127711/pdf/1114.pdf  a1010-30 v703 a<p>The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.</p>  a0019-9567