01220nas a2200241   4500000000100000008004100001260001700042653002700059653001200086653001400098653001100112653001200123653002500135653001800160653001700178100001400195245009000209300000800299490000700307050001600314520063400330022001400964       2002                            d  c2002 Jan-Feb10aAllergy and Immunology10aAnimals10aCytokines10aHumans10aleprosy10aMycobacterium leprae10aT-Lymphocytes10aTuberculosis1 aModlin RL00aLearning from leprosy: insights into contemporary immunology from an ancient disease.  a1-60 v15  aMODLIN 20023 a<p>Leprosy provides an ideal model to study immune responses in humans and in skin. Learning from leprosy, we have gained insight into mechanisms of host resistance and susceptibility to infection. New paradigms include the role of Th1/Th2 cytokines, the ability of CD1 to present nonpeptide antigens to T cells, the ability of microbial lipoproteins to stimulate antimicrobial activity in monocytes and the demonstration that T cells can mediate a direct antimicrobial activity through release of granulysin. Together, these findings provide a rationale for developing new strategies to treat and prevent infectious disease.</p>  a1422-2868