01073nas a2200241   4500000000100000008004100001260001300042653001400055653002100069653002200090653001100112653001200123653002500135100001600160700001400176245012900190856005900319300001100378490000700389050001700396520040400413022001400817       2001                            d  c2001 Dec10aCell Wall10aGenes, Bacterial10aGenome, Bacterial10aHumans10aleprosy10aMycobacterium leprae1 aBrennan P J1 aVissa V D00aGenomic evidence for the retention of the essential mycobacterial cell wall in the otherwise defective Mycobacterium leprae.  uhttp://leprev.ilsl.br/pdfs/2001/v72n4/pdf/v72n4a05.pdf  a415-280 v72  aBRENNAN 20013 a<p>The obligate intracellularism of Mycobacterium leprae may be attributable to the effects of mutations in major metabolic areas due to a genome capable of encoding only about 1600 proteins. Yet cell wall biosynthesis capability remains relatively intact and comparisons with the genome of Mycobacterium tuberculosis provide insights into the genetic basis of a minimal mycobacterial cell wall.</p>  a0305-7518