01975nas a2200241   4500000000100000008004100001653001100042653000800053653002500061653002400086653001600110653001300126653001400139100001200153700001400165700001200179700001500191700001700206245008300223490001200306520140100318022001401719       2015                            d10aReview10aPRP10aPlatelet-rich plasma10aFacial rejuvenation10aDermatology10aCosmetic10aAesthetic1 aLeo M S1 aKumar A S1 aKirit R1 aKonathan R1 aSivamani R K00aSystematic review of the use of platelet-rich plasma in aesthetic dermatology.0 v23 July3 a<p>Platelet-rich plasma (PRP) is a highly concentrated autologous solution of plasma prepared from a patient's own blood. PRP contains platelets that are purported to release numerous growth factors that may be valuable in numerous dermatologic applications. Here, we review systematically the clinical cosmetic applications of PRP including: androgenetic alopecia, scar revision, acne scars, skin rejuvenation, dermal augmentation, and striae distensae to understand the potential and best practices for PRP use. A systematic search was conducted on three databases: Pubmed, Embase, and Web of Science. Publications were included if they were in English, investigated the clinical applications of PRP in aesthetic dermatology and reported clinical results either as case reports or clinical studies. There were a total of 22 manuscripts that fulfilled these criteria. Four evaluated hair-related applications, eight evaluated the treatment of scars and postprocedure recovery, eight evaluated skin rejuvenation and dermal augmentation, and two evaluated treatment of striae distensae. PRP is a relatively new treatment modality with studies suggesting its utility in aesthetic dermatology. The combination of PRP with other therapies is particularly interesting. Future studies should include controls, including incorporation of split-face comparisons, to reduce intersubject variability.</p>
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