01160nas a2200205   4500000000100000008004100001653002000042653003200062653001000094653001700104100001000121700001000131700001400141700001100155245007200166856007600238300001200314490000700326520062100333       2015                            d10aType 1 reaction10aTumor Necrosis Factor-alpha10aIndia10aChemotherapy1 aDas S1 aDas S1 aGhoshal L1 aMalo S00aLeprosy: type 1 reaction precipitated by doxorubicin and cisplatin.  uhttp://www.jpad.org.pk/Jan-March-2015/12.%20Case%20report%20Leprosy.pdf  a55–570 v253 a<div dir="ltr">Type 1 reaction (T1R) in leprosy is common and characterized by increased inflammation in skin lesions or nerve. Besides antileprotic therapy, T1Rs are associated with intercurrent infection,pregnancy and drugs. Also, T1Rs may be a presenting feature ofleprosy. We report a case of T1Rin leprosy presenting as drug reaction during cancer chemotherapy with doxorubicin and cisplatin.We propose to explain this unusual occurrence by highlighting the increased production and expression of TNF-α by these drugs. Thus, physicians using these drugs should keep this unusual adverse effect in mind.</div>