01280nas a2200241   4500000000100000008004100001653001400042653001700056653001200073653001000085653002100095653001200116100001500128700001000143700001200153700001600165245005600181856007100237300001100308490000700319520069800326022001401024       2014                            d10aTreatment10aSide effects10aleprosy10aIndia10aHypersensitivity10aDapsone1 aPereira CM1 aVaz M1 aKotha S1 aSantosh N H00aDapsone hypersensitivity syndrome with myocarditis.  uhttp://www.japi.org/august_2014/16_cr_dapsone_hypersensitivity.pdf  a728-310 v623 a<p>Drug hypersensitivity with myocarditis is known to occur with many drugs especially with antiepileptics, sulpha-compounds and daposne. Dapsone (4, 4 diaminodiphenyl sulphone) induced hypersensitivity is known to occur in about 2% of leprosy patients on treatment and an incidence of 1.66% in non-leprosy patients. We report this rare case of dapsone hypersensitivity syndrome in a girl on dapsone who presented with fever, anaemia, jaundice, skin rash, lymphadenopathy, and hepatomegaly and later developed myocarditis. The drug was withdrawn and the patient was treated with steroids. She improved and was discharged. She relapsed after the corticosteroids were discontinued at home.</p>
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