01542nas a2200229   4500000000100000008004100001653001900042653001400061653001700075653001200092653001200104653002100116100001400137700001400151700001200165700001400177245008500191856005100276300001200327490000700339520096600346       2014                            d10aSweet Syndrome10aReactions10aPathogenesis10aMimicry10aleprosy10aErythema Nodosum1 aMahajan V1 aAbhinav C1 aMehta K1 aChauhan S00aErythema nodosum leprosum mimicking Sweet’s syndrome: an uncommon presentation  uhttps://leprosyreview.org/article/85/4/32-2327  a322-3270 v853 a<div dir="ltr">Erythema nodosum leprosum (ENL) lesions may uncommonly develop ulceration, necrosis, pustulation or bullae. This 60year-old female was hospitalised with previously undiagnosed multibacillary (BL) leprosy and Sweet’s syndrome-like ENL, a presentation that is rarely reported. In addition to skin lesions simulating Sweet’s syndrome, she had anaemia, elevated ESR, and a peripheral leucocytosis with neutrophilia, the laboratory features of Sweet’s syndrome. The final diagnosis was made from chronic iridocyclitis, presence of lepra bacilli in slit-skin smears, and histology. The pathogenesis of Sweet’s-like ENL remains conjectural. In Sweet’s syndrome a complex interplay of various cytokines leading to an abundance of pro-inflammatory cytokines in the target tissues has been postulated to initiate an abnormal tissue response to certain antigens; such findings may eventually explain these uncommon lepra reactions as well.</div>