01329nas a2200217   4500000000100000008004100001653001600042653001200058653001000070653001200080653002600092100002200118700002100140700001400161245008500175856005600260300001200316490000600328050002400334520075300358       2015                            d10aClofazimine10aDapsone10aIndia10aleprosy10aPeripheral neuropathy1 aVengadakrishnan L1 aGowtam Mukhesh L1 aKoushik A00aProlonged use of multidrug therapy for leprosy leading to multiple complications  uhttp://www.jebmh.com/data_pdf/1_Vengadakrishnan.pdf  a200-2050 v2  aVENGADAKRISHNAN20153 a<p>Multidrug therapy (MDT) for leprosy was recommended by WHO with a triple drug regimen of Dapsone, Rifampicin and Clofazimine, which is still the best treatment for leprosy. Side effects of these are commonly seen in clinical practice. Herein we present to you a case of 63 year old male patient who presented to the OPD with gastro-intestinal symptoms, paresthesias and difficulty in walking. It was only by proper history taking (he has been continuing MDT for the past 43 years), the diagnosis could be made. Further workup revealed presence of methemoglobinemia, atrophic gastritis, peripheral neuropathy and subacute combined degeneration of spinal cord. Prompt treatment and withdrawal of the drug lead to improvement of the symptoms.</p>