01482nas a2200457 4500000000100000008004100001260001300042653001200055653002600067653003200093653001800125653001600143653001900159653003100178653003000209653002100239653001100260653002300271653001200294653000900306653002800315653002500343653001400368653005200382653001300434100001200447700001500459700001300474700001000487700001200497700001600509700001300525700001600538700001800554245007300572300001100645490000700656050001500663520033200678022001401010 2001 d c2001 Dec10aAnimals10aAnti-Infective Agents10aAntibiotics, Antitubercular10aBase Sequence10aDNA Primers10aDNA, Bacterial10aDrug Resistance, Microbial10aDrug Resistance, Multiple10aGenes, Bacterial10aHumans10aLeprostatic Agents10aleprosy10aMice10aMolecular Sequence Data10aMycobacterium leprae10aOfloxacin10aReverse Transcriptase Polymerase Chain Reaction10aRifampin1 aMaeda S1 aMatsuoka M1 aNakata N1 aKai M1 aMaeda Y1 aHashimoto K1 aKimura H1 aKobayashi K1 aKashiwabara Y00aMultidrug resistant Mycobacterium leprae from patients with leprosy. a3635-90 v45 aMAEDA 20013 a
Sequences of the folP1, rpoB, and gyrA genes were analyzed for 88 isolates of Mycobacterium leprae from leprosy patients in Japan, Haiti, Indonesia, Pakistan, and the Philippines. Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae.
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