01276nas a2200121   4500000000100000008004100001653001400042100002500056245003800081856011100119520091000230022001401140       2014                            d10aPsoriasis1 aRomaní de Gabriel J00aDarwinian Medicine and Psoriasis.  uhttp://www.actasdermo.org/en/linkresolver/medicina-darwiniana-psoriasis/S0001-7310(14)00364-0/?pubmed=true3 a<p>Darwinian medicine, or evolutionary medicine, regards some pathological conditions as attempts by the organism to solve a problem or develop defense mechanisms. At certain stages of human evolution, some diseases may have conferred a selective advantage. Psoriasis is a high-penetrance multigenic disorder with prevalence among whites of up to 3%. Psoriatic lesions have been linked with enhanced wound-healing qualities and greater capacity to fight infection. Leprosy, tuberculosis, and infections caused by viruses similar to human immunodeficiency virus have been postulated as environmental stressors that may have selected for psoriasis-promoting genes in some human populations. The tendency of patients with severe psoriasis to develop metabolic syndrome may reflect the body's attempt to react to environmental stresses and warning signs by triggering insulin resistance and fat storage.</p>
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