01357nas a2200241   4500000000100000008004100001260001300042653001100055653000900066653001200075653001100087653002000098653001100118653002100129100001200150700001500162245008100177856005900258300001000317490000700327520076700334022001401101       1993                            d  c1993 Dec10aUganda10aMale10aleprosy10aHumans10aHospitalization10aFemale10aErythema Nodosum1 aBwire R1 aKawuma H J00aHospital-based epidemiological study of reactions, Buluba Hospital, 1985-89.  uhttp://leprev.ilsl.br/pdfs/1993/v64n4/pdf/v64n4a06.pdf  a325-90 v643 a<p>A retrospective study of 256 reactional episodes, both reversal reaction and erythema nodosum leprosum (ENL), seen in Buluba Hospital over a 5-year period (1985-89) was made. Over 90% of these episodes were due to reversal reaction, with ENL being encountered infrequently. About 80% of reversal reactions occurred during chemotherapy but all the episodes of ENL occurred during this period. Over 70% of both reversal and ENL episodes presented with clinically apparent nerve and skin involvement. The need to assess the effect of multidrug therapy on the incidence of reactions and to develop more sensitive diagnostic tools to detect early neuritis is emphasized. It is also necessary to study those patients who develop recurrent reactional episodes.</p>
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