01531nas a2200289   4500000000100000008004100001260001700042653001300059653001300072653001600085653000900101653001200110653001100122653001900133653001100152653001000163653000900173653001000182653001500192100001200207700001500219245011100234300001000345490000700355520086500362022001401227       1994                            d  c1994 May-Jun10aSteroids10aNeuritis10aMiddle Aged10aMale10aleprosy10aHumans10aHIV Infections10aFemale10aChild10aAged10aAdult10aAdolescent1 aBwire R1 aKawuma H J00aType 1 reactions in leprosy, neuritis and steroid therapy: the impact of the human immunodeficiency virus.  a315-60 v883 a<p>The incidence of type 1 reactions and neuritis among HIV seronegative and HIV seropositive leprosy patients was investigated. HIV seropositivity was associated with an increased incidence of type 1 reactions among multibacillary (MB) patients, which were observed in 9 of 12 seropositive MB patients and in 8 of 40 HIV seronegative MB patients (P < 0.0005). Similarly, the incidence of neuritis was significantly increased among the HIV seropositive MB patients, of whom 8 developed acute neuritis compared to 3 of the HIV seronegative patients (P < 0.0005). There was no significant difference between the numbers of paucibacillary HIV seropositive and HIV seronegative patients who developed these complications. Both the HIV seronegative and HIV seropositive patients showed a similar response to steroid therapy for the management of acute neuritis.</p>  a0035-9203