01927nas a2200337   4500000000100000008004100001260001300042653001100055653002100066653001700087653001500104653001600119653000900135653001200144653001100156653002300167653001900190653001100209653002500220653001000245653001500255100001500270700001200285700001900297245009700316856004100413300001000454490000700464520110400471022001401575       1994                            d  c1994 Dec10aUganda10aSex Distribution10aRisk Factors10aOdds Ratio10aMiddle Aged10aMale10aleprosy10aHumans10aHIV Seropositivity10aHIV Infections10aFemale10aCase-Control Studies10aAdult10aAdolescent1 aKawuma H J1 aBwire R1 aAdatu-Engwau F00aLeprosy and infection with the human immunodeficiency virus in Uganda; a case-control study.  uhttp://ila.ilsl.br/pdfs/v62n4a03.pdf  a521-60 v623 a<p>Both leprosy and infection with the human immunodeficiency virus (HIV) are endemic in Uganda. Various speculations about a possible interaction between the two infections have been put forward but not confirmed. A case-control study involving 189 new leprosy patients and 481 matched controls, resident in eight Ugandan districts, was carried out to investigate if any relationship exists between leprosy and infection with HIV-1 in Uganda. Serum samples from 23 (12.2%) of the 189 leprosy patients tested positive for HIV-1 antibodies as compared to 88 (18.3%) of the 481 control sera. The two proportions of HIV seropositivity are not different statistically. A stratified analysis of the data by districts was done and showed a negative relationship between leprosy and HIV infection in the case of Rakai District (0.04 < odds ratio < 0.61, p = 0.002). It is recommended that studies seeking to observe the clinical progress of dually infected patients might help to reveal new knowledge about a possible relationship between HIV and leprosy and about the immunology of leprosy in general.</p>  a0148-916X