01822nas a2200301   4500000000100000008004100001260001300042653001100055653002300066653001300089653001100102653001700113653001300130653003100143653001100174653002800185653001200213653000900225653001300234100001700247700001500264700001500279245010800294300001100402490000700413520108600420022001401506       1980                            d  c1980 Aug10aBrazil10aChromosome Mapping10aEpitopes10aFemale10aHLA Antigens10aHaploidy10aHistocompatibility Testing10aHumans10aIndians, South American10aleprosy10aMale10aPedigree1 aLawrence D N1 aBodmer J G1 aBodmer W F00aDistribution of HLA  antigens in Ticuna Indians of Brazil: results of typing a leprosy-affected family.  a152-600 v163 a<p>HLA typing was performed in 1978, using antisera recognizing specificities defined by the Seventh Workshop, on lymphocytes separated and frozen in the field during a 1976 expedition among Amazonian Ticuna Indians. Family segregation of HLA antigens was used to ascertain haplotypes of a sample of essentially unrelated reproductive-age adults. "Expaternal" haplotypes were also included in the total of 81 haplotypes used for calculating the A and B locus gene frequencies. Common A and B locus antigens among the Ticuna were Aw24, Aw31, A2, Bw39, B40, Bw35, and B15.1. Bw53 were also present. No A or B locus "blanks" were found. A slight degree of European admixture was apparent. Bw16-reactive cells from certain persons consistently failed to react with Oxford antisera capable of recognizing the Bw38 or Bw39 subspecificities. Cw1 and Cw3 were found in association with typical South American Indian haplotypes. The results of HLA typing of a large extended family with multiple cases of leprosy are depicted and compared to recently reported family studied of leprosy.</p>  a0001-2815