02363nas a2200241   4500000000100000008004100001260001300042100001400055700001500069700001200084700001300096700001900109700002000128700001500148700001500163700001700178245006700195856007200262300001100334490000700345520175500352022001402107       2014                            d  c2014 Jan1 aTruman RW1 aEbenezer G1 aPena MT1 aSharma R1 aBalamayooran G1 aGillingwater TH1 aScollard D1 aMcArthur J1 aRambukkana A00aThe armadillo as a model for peripheral neuropathy in leprosy.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158350/pdf/ilt050.pdf  a304-140 v543 a<p>Leprosy (also known as Hansen's Disease) is a chronic infectious disease caused by Mycobacterium leprae that primarily targets the peripheral nervous system; skin, muscle, and other tissues are also affected. Other than humans, nine-banded armadillos (Dasypus novemcinctus) are the only natural hosts of M. leprae, and they are the only laboratory animals that develop extensive neurological involvement with this bacterium. Infection in the armadillo closely recapitulates many of the structural, physiological, and functional aspects of leprosy seen in humans. Armadillos can be useful models of leprosy for basic scientific investigations into the pathogenesis of leprosy neuropathy and its associated myopathies, as well as for translational research studies in piloting new diagnostic methods or therapeutic interventions. Practical and ethical constraints often limit investigation into human neuropathies, but armadillos are an abundant source of leprotic neurologic fibers. Studies with these animals may provide new insights into the mechanisms involved in leprosy that also might benefit the understanding of other demyelinating neuropathies. Although there is only a limited supply of armadillo-specific reagents, the armadillo whole genomic sequence has been completed, and gene expression studies can be employed. Clinical procedures, such as electrophysiological nerve conduction testing, provide a functional assessment of armadillo nerves. A variety of standard histopathological and immunopathological procedures including Epidermal Nerve Fiber Density (ENFD) analysis, Schwann Cell Density, and analysis for other conserved cellular markers can be used effectively with armadillos and will be briefly reviewed in this text.</p>
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