02485nas a2200337   4500000000100000008004100001260000900042653002000051653001000071653001700081100001400098700001700112700001700129700002000146700002100166700001400187700002100201700001400222700002100236700002400257700001200281700001500293700001500308245015000323856007800473300001000551490000600561050001600567520155000583022001402133       2013                            d  c201310aPrevalence rate10aCongo10aBuruli ulcer1 aPhanzu DM1 aSuykerbuyk P1 aSaunderson P1 aNgwala Lukanu P1 aMasamba Minuku J1 aImposo DB1 aMbadu Diengidi B1 aKayinua M1 aTamfum Muyembe J1 aTshindele Lutumba P1 aJong BC1 aPortaels F1 aBoelaert M00aBurden of Mycobacterium ulcerans disease (Buruli Ulcer) and the underreporting ratio in the territory of Songololo, Democratic Republic of Congo.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855042/pdf/pntd.0002563.pdf  ae25630 v7  aPHANZU 20133 a<p>BACKGROUND: Cutaneous infection by Mycobacterium ulcerans, also known as Buruli ulcer (BU), represents the third most common mycobacterial disease in the world after tuberculosis and leprosy. Data on the burden of BU disease in the Democratic Republic of Congo are scanty. This study aimed to estimate the prevalence rate and the distribution of BU in the Songololo Territory, and to assess the coverage of the existing hospital-based reporting system. METHODS: We conducted a cross-sectional survey (July-August 2008) using the door-to-door method simultaneously in the two rural health zones (RHZ) of the Songololo Territory (RHZ of Kimpese and Nsona-Mpangu), each containing twenty health areas. Cases were defined clinically as active BU and inactive BU in accordance with WHO-case definitions. RESULTS: We detected 775 BU patients (259 active and 516 inactive) in a total population of 237,418 inhabitants. The overall prevalence of BU in Songololo Territory was 3.3/1000 inhabitants, varying from 0 to 27.5/1000 between health areas. Of the 259 patients with active BU, 18 (7%) had been reported in the hospital-based reporting system at Kimpese in the 6-8 months prior to the survey. CONCLUSION: The survey demonstrated a huge variation of prevalence between health areas in Songololo Territory and gross underreporting of BU cases in the hospital-based reporting system. Data obtained may contribute to better targeted and improved BU control interventions, and serve as a baseline for future assessments of the control program.</p>
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