01360nas a2200181   4500000000100000008004100001653001200042653001900054653001500073653001100088100001400099245006000113856006100173300001200234490000700246050001500253520091000268       2013                            d10aleprosy10aHistopathology10aImmunology10aMexico1 aBravo T C00aNew observations on the polar spectrum of human leprosy  uhttp://www.medigraphic.com/pdfs/patol/pt-2013/pt134b.pdf  a205-2230 v60  aBRAVO 20133 aLeprosy is a chronic granulomatous infection of the skin and peripherial nerves, caused by Mycobacterium leprae. 
Leprosy clinical diagnosis should be considered whenever skin lesions and sensory loss occur. Recent immunologic 
research, classic bacteriological methods and histopathology, molecular bacteriology and the Ridley-Jopling 
(RJ) classifi cation which recognized clinical-types not as separate entities, but merely segments of a wide spectrum
ranging from purely localized, hyperergic, tuberculoid (TT) pole, trough the borderline (B) types, to the generalized, 
anergic lepromatous (LL) pole. Reactive episodes continue to be a serious complication, but the availability of 
thalidomide and clofazimine to control erythema nodosum leprosum, has much improved the prognosis. This review 
summarises recent advances in understanding the clinical features and pathogenesis of the disease.