02460nas a2200385   4500000000100000008004100001260001600042653001500058653001000073653003700083653001000120653002700130653001800157653001100175653001500186653001100201653001900212653001200231653000900243653003600252653003000288100001300318700001400331700001100345700001000356700001000366700001000376700001300386700001100399245009300410300001200503490000700515520153800522022001402060       2013                            d  c2013 Aug 1210aAdolescent10aAdult10aAsian Continental Ancestry Group10aChina10aDisease Susceptibility10aEthnic Groups10aFemale10aHaplotypes10aHumans10aInterleukin-1010aleprosy10aMale10aPolymorphism, Single Nucleotide10aPromoter Regions, Genetic1 aChen X H1 aXiong J H1 aNing Y1 aWen Y1 aLiu J1 aMao C1 aWeng X M1 aGu J C00aIL-10 promoter SNPs and susceptibility to leprosy in ethnic groups from southwest China.  a2876-850 v123 a<p>The purpose of this study was to determine whether interleukin-10 (IL-10) promoter polymorphisms are associated with leprosy or their subtypes in ethnic groups from southwest China. Genotyping using TaqMan® SNP Genotyping Master Mix and ABI 7500 real-time PCR system was performed for IL-10 T3575A, G2849A, C2763A, A1082G, C819T, and C592A in 189 healthy controls (40 ± 18 years) and 193 patients (46 ± 18 years) with leprosy [multibacillary, N = 131; paucibacillary (PB), N = 62]. The allelic frequencies of -2763C (97.9 vs 94.0%, P = 0.0074) and -1082A (92.8 vs 88.6%, P = 0.0452) in leprosy patients were significantly higher than in control subjects. The genetic frequency of -2763CC and -1082AA was not only significantly higher among leprosy patients than among control subjects [odds ratio (OR) = 3.33, 95% confidence interval (95%CI) = 1.39-7.99, P = 0.0071 and OR = 1.76, 95%CI = 1.02-3.03, P = 0.0420, respectively] but also significantly higher among PB patients than among control subjects (OR = 2.46, 95%CI = 1.22-4.96, P = 0.0115 and OR = 5.58, 95%CI = 2.06-15.12, P = 0.0007, respectively). The frequency of IL-10 haplotype 3575A/2849G/2763A/1082G/819C/592C was significantly higher among leprosy patients (OR = 5.57, 95%CI = 1.13-27.52, P = 0.0351) and PB patients (OR = 10.5, 95%CI = 1.36- 81.05, P = 0.0241) than among control subjects. IL-10 promoter -2763C/CC,-1082A/AA and haplotype 3575A/2849G/2763A/1082 G/819C/592C are associated with susceptibility to leprosy and the PB subtype in southwest China.</p>  a1676-5680