01463nas a2200229   4500000000100000008004100001653002400042653001900066653001000085653001200095100002000107700001300127700001900140700001600159700001100175245006300186856005000249300001400299490000600313050002300319520089100342       2013                            d10alepromatous leprosy10aHistopathology10aIndia10aleprosy1 aBandyopadhyay A1 aMondal K1 aGangopadhyay M1 aMallick MSG1 aGiri A00aDe-novo presentation of histoid leprosy on an unusual site  uhttp://iranpath.org/IJPArticles/8_4/11-32.pdf  a277 - 2800 v8  aBANDYOPADHYAY 20133 aHistoid Leprosy (HL) is a rare variant of Lepromatous Leprosy, occurring in long-standing cases, mostly in a background of acquired drug resistance. Patients usually present with sudden onset multiple nodules and plaques, most often involving the skin and subcutaneous tissue of trunk and lower limbs. Here we report an unusual case of de novo (without any history of prior anti-leprotic therapy) HL, arising as multiple nodules in the face. The histopathology of the lesion showed collection of spindled macrophages in the dermis, oriented in a storiform-like pattern. A possibility of HL was considered and the diagnosis was confirmed by performing a modified ZN stain (Wade-Fite stain) on the biopsy material, which revealed the presence of acid-fast bacilli (AFB) with a bacillary index of 6. Then the patient was put on multibacillary multi-drug chemotherapy and was thereby cured.